Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670174 | 0.82 | MAPK14 (0.54) | MAPK14MAPK11MAPK13MAPK12KMT2A | |
| SCHEMBL9192753 | 0.74 | RAF1 (0.44) | MAPK14KMT2AMEN1GAANOTUM | |
| SCHEMBL4732955 | 0.73 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12KMT2A | |
| SCHEMBL6669570 | 0.73 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL4732271 | 0.71 | SUV39H2 (0.37) | MAPK14MAPK11MAPK13MAPK12KMT2A | |
| SCHEMBL6672947 | 0.70 | MAPK14 (0.69) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6670099 | 0.69 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL4068301 | 0.68 | MAPK14 (0.46) | MAPK14KMT2AMEN1GAA | |
| SCHEMBL6667200 | 0.68 | MAPK14 (0.56) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6667920 | 0.68 | MAPK14 (0.71) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |