Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14203905 | 0.84 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6672601 | 0.77 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4732955 | 0.76 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL4730689 | 0.71 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL6670174 | 0.69 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL20010985 | 0.67 | HTR2C (0.47) | SUV39H2IKBKETBK1 | |
| SCHEMBL14337345 | 0.67 | SUV39H2 (0.40) | SUV39H2IKBKETBK1 | |
| SCHEMBL23484640 | 0.66 | SUV39H2 (0.45) | SUV39H2IKBKETBK1GAA | |
| SCHEMBL14403246 | 0.66 | TBK1 (0.43) | SUV39H2IKBKETBK1 | |
| SCHEMBL20010988 | 0.65 | SUV39H2 (0.40) | SUV39H2MAPK14IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |