SCHEMBL4730705

SCHEMBL4730705

COc1ccc(-c2cccc(C(=O)NCCC(c3ccc(Cl)cc3)N(C)C)c2)cc1

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.65
MAPK1 P28482 1/20 0.54
KDM4E B2RXH2 1/20 0.54
ALDH1A1 P00352 1/20 0.54
HPGD P15428 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4733066 0.93 UTS2R (0.60) UTS2R
SCHEMBL4731222 0.91 UTS2R (0.64) UTS2RMAPK1KDM4EALDH1A1HPGD
SCHEMBL4729679 0.90 UTS2R (0.61) UTS2RALDH1A1HPGDSMN1; SMN2
SCHEMBL4732737 0.90 UTS2R (0.61) UTS2R
SCHEMBL4731475 0.89 UTS2R (0.63) UTS2R
SCHEMBL4732375 0.87 UTS2R (0.65) UTS2RMAPK1KDM4EALDH1A1HPGD
SCHEMBL4729682 0.87 UTS2R (0.64) UTS2R
SCHEMBL4730440 0.86 UTS2R (0.65) UTS2R
SCHEMBL4731502 0.82 UTS2R (0.55) UTS2RHPGDSMN1; SMN2
SCHEMBL4728770 0.81 UTS2R (0.63) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008057543-A2 UII-MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2008-05-15 WO claimed
WO-2008057543-A2 UII-MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2008-05-15 WO disclosed