SCHEMBL4732737

SCHEMBL4732737

CN(C)C(CCNC(=O)c1cccc(-c2ccccc2)c1)c1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.61
ALOX5 P09917 1/20 0.48
EPHX2 P34913 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4733066 0.97 UTS2R (0.60) UTS2R
SCHEMBL4731475 0.93 UTS2R (0.63) UTS2R
SCHEMBL4729682 0.91 UTS2R (0.64) UTS2R
SCHEMBL4734176 0.90 UTS2R (0.60) UTS2REPHX2
SCHEMBL4730440 0.90 UTS2R (0.65) UTS2R
SCHEMBL4730705 0.90 UTS2R (0.65) UTS2R
SCHEMBL4733409 0.86 UTS2R (0.61) UTS2R
SCHEMBL4731502 0.85 UTS2R (0.55) UTS2R
SCHEMBL4728770 0.84 UTS2R (0.63) UTS2R
SCHEMBL4729141 0.82 TMEM97 (0.55) UTS2REPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008057543-A2 UII-MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2008-05-15 WO claimed
WO-2008057543-A2 UII-MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2008-05-15 WO disclosed