⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10961131 | 0.76 | — | — | |
| SCHEMBL387713 | 0.74 | — | — | |
| Fluoroacetate SCHEMBL27881898 | 0.70 | — | — | |
| SCHEMBL8921548 | 0.70 | — | — | |
| SCHEMBL230901 | 0.70 | — | — | |
| SCHEMBL79002 | 0.70 | — | — | |
| Bicarbonate SCHEMBL20423895 | 0.68 | FFAR3 (0.40) | — | |
| SCHEMBL27731102 | 0.67 | — | — | |
| SCHEMBL13651723 | 0.67 | — | — | |
| SCHEMBL18632357 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442945-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SRL (BE) | 2020-07-08 | — | — | EP | claimed |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2019-08-06 | — | — | US | claimed |
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2019-04-11 | — | — | US | claimed |
| EP-3442945-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SPRL (BE) | 2019-02-20 | — | — | EP | claimed |
| CN-108884050-A | Tetrahydroisoquinoline derivatives | UCB生物制药私人有限公司 | 2018-11-23 | — | — | CN | claimed |
| WO-2017178377-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2017-10-19 | — | — | WO | claimed |
| CN-103732596-B | Pyrrolopyrimidine derivatives | NOVARTIS AG (CH) | 2016-06-01 | — | — | CN | claimed |
| CN-102952059-A | Amide derivative and preparation method thereof, medicine composition and application | SHANGHAI PHARMACEUTICALS HOLDING CO LTD | 2013-03-06 | — | — | CN | claimed |
| CN-102351918-A | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing said compounds, their use and process for their preparation | BOEHRINGER INGELHEIM INT | 2012-02-15 | — | — | CN | claimed |
| CN-101790520-A | Method for preparing halogenated amines | WYETH CORP | 2010-07-28 | — | — | CN | claimed |
| CN-101437807-A | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing said compounds, their use and process for their preparation | BOEHRINGER INGELHEIM INT (DE) | 2009-05-20 | — | — | CN | claimed |
| CN-101400653-A | 11-beta HSD1 inhibitors | WYETH CORP (US) | 2009-04-01 | — | — | CN | claimed |
| CN-101384576-A | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INT (DE) | 2009-03-11 | — | — | CN | claimed |
| EP-3442945-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SRL (BE) | 2020-07-08 | — | — | EP | disclosed |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2019-08-06 | — | — | US | disclosed |
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2019-04-11 | — | — | US | disclosed |
| US-4251534-A | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4251534-A | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4218448-A | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-08-19 | — | — | US | disclosed |
| US-4218448-A | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-08-19 | — | — | US | disclosed |