Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 9/20 | 0.46 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.46 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 8/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 8/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 8/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733849 | 0.97 | GRIN1 (0.48) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL3190483 | 0.97 | GRIN1 (0.48) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Hydrochloric Acid SCHEMBL28669825 | 0.94 | GRIN1 (0.50) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Methyl Alcohol SCHEMBL28225130 | 0.91 | TSHR (0.48) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Dimethylamine SCHEMBL4774387 | 0.88 | GRIN1 (0.50) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Ethylamine SCHEMBL27587053 | 0.84 | MEN1 (0.48) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL28873726 | 0.82 | TSHR (0.43) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Acetamide SCHEMBL2553577 | 0.80 | TSHR (0.50) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Ammonia Solution, Strong SCHEMBL4435086 | 0.80 | EPHX2 (0.38) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL986398 | 0.78 | PKM (0.52) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008062472-A2 | PROCESS FOR THE PREPARATION OF MEMANTINE | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |