Aziridine

Aziridine

SCHEMBL4732220

C1CN1.N=C1CCNC1=O

nearest known ligand 0.43

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Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 2/20 0.43
PARP10 Q53GL7 10/20 0.35
PARP1 P09874 8/20 0.35
PARP11 Q9NR21 6/20 0.35
PDPK1 O15530 1/20 0.35
MAP2K1 Q02750 2/20 0.33
F7 P08709 1/20 0.31
F3 P13726 1/20 0.31
ACHE P22303 1/20 0.31
OR51E2 Q9H255 1/20 0.31
KDM4E B2RXH2 2/20 0.31
RAF1 P04049 1/20 0.31
MAPK1 P28482 1/20 0.31
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
HPGD P15428 1/20 0.31
CYP2C19 P33261 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4729347 0.95
SCHEMBL11308019 0.79
SCHEMBL21635931 0.75
SCHEMBL22216329 0.70 CRBN (0.35) CRBNPARP10PARP1PARP11PDPK1
SCHEMBL3991717 0.67 KDR (0.43) CRBNPARP10PARP1PARP11PDPK1
SCHEMBL21745644 0.67 KDR (0.43) CRBNPARP10PARP1PARP11PDPK1
Piperazine SCHEMBL28119295 0.67 KDR (0.43) CRBNPARP10PARP1PARP11PDPK1
Piperazine SCHEMBL28231072 0.65 KDR (0.40) CRBNPARP10PARP1PARP11PDPK1
SCHEMBL116223 0.65
SCHEMBL21892287 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008045998-A3 ENANTIOMERICALLY ENRICHED IMINOPYRROLIDONE AZIRIDINE COMPOSITIONS UNIV ARIZONA (US) 2008-09-18 WO disclosed
WO-2008045686-A3 ENANTIOMERICALLY ENRICHED IMINOPYRROLIDONE AZIRDINE COMPOSITIONS UNIV ARIZONA (US) 2008-07-24 WO disclosed
WO-2008045686-A2 ENANTIOMERICALLY ENRICHED IMINOPYRROLIDONE AZIRDINE COMPOSITIONS THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2008-04-17 WO disclosed
WO-2008045998-A2 ENANTIOMERICALLY ENRICHED IMINOPYRROLIDONE AZIRIDINE COMPOSITIONS THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2008-04-17 WO disclosed
WO-2008045998-A2 ENANTIOMERICALLY ENRICHED IMINOPYRROLIDONE AZIRIDINE COMPOSITIONS THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2008-04-17 WO disclosed
WO-2008045686-A2 ENANTIOMERICALLY ENRICHED IMINOPYRROLIDONE AZIRDINE COMPOSITIONS THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2008-04-17 WO disclosed