Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735643 | 0.91 | FASN (0.58) | FASNALDH1A1MAPT | |
| SCHEMBL4734984 | 0.88 | FASN (0.73) | FASNALDH1A1 | |
| SCHEMBL4783035 | 0.85 | FASN (0.65) | FASN | |
| SCHEMBL4737601 | 0.85 | FASN (0.59) | FASNALDH1A1MEN1KMT2AGAA | |
| SCHEMBL14210096 | 0.84 | FASN (0.55) | FASNALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL4731259 | 0.83 | SMN1; SMN2 (0.54) | FASNALDH1A1MEN1KMT2AGAA | |
| SCHEMBL4782078 | 0.80 | MAPK14 (0.56) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL4737589 | 0.80 | FASN (0.67) | FASNALDH1A1 | |
| SCHEMBL4734907 | 0.80 | FASN (0.71) | FASN | |
| SCHEMBL19396043 | 0.80 | FASN (0.85) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |