Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781974 | 0.90 | MCHR1 (0.49) | MCHR1 | |
| SCHEMBL4888566 | 0.85 | MCHR1 (0.73) | MCHR1DPP4KCNH2DPP8DPP9 | |
| SCHEMBL4732127 | 0.85 | MCHR1 (0.73) | MCHR1DPP4KCNH2DPP8DPP9 | |
| SCHEMBL4891076 | 0.85 | MCHR1 (0.55) | MCHR1DPP4CHRM4KCNH2DPP8 | |
| SCHEMBL4887824 | 0.82 | MCHR1 (0.47) | MCHR1DPP4CHRM4KCNH2DPP8 | |
| SCHEMBL4731538 | 0.81 | MCHR1 (0.53) | MCHR1DPP4KCNH2DPP8DPP9 | |
| SCHEMBL4877733 | 0.80 | MCHR1 (0.71) | MCHR1DPP4KCNH2DPP8DPP9 | |
| SCHEMBL4796076 | 0.80 | MCHR1 (0.65) | MCHR1DPP4KCNH2DPP8DPP9 | |
| SCHEMBL14223178 | 0.79 | MCHR1 (0.54) | MCHR1KCNH2 | |
| SCHEMBL4732285 | 0.78 | MCHR1 (0.51) | MCHR1DPP4KCNH2DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041090-A1 | MALANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONIST PYRIDINONES | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |