Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.51 |
| ▸ | SCD | O00767 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732124 | 0.85 | MCHR1 (0.73) | MCHR1SCDDPP4CYP3A4KCNH2 | |
| SCHEMBL4888561 | 0.85 | MCHR1 (0.73) | MCHR1SCDDPP4CYP3A4KCNH2 | |
| SCHEMBL4731538 | 0.81 | MCHR1 (0.53) | MCHR1DPP4MAPTCYP3A4KCNH2 | |
| SCHEMBL4887824 | 0.80 | MCHR1 (0.47) | MCHR1SCDDPP4ALDH1A1KDM4E | |
| SCHEMBL4796070 | 0.80 | MCHR1 (0.65) | MCHR1SCDDPP4CYP3A4KCNH2 | |
| SCHEMBL14223178 | 0.79 | MCHR1 (0.54) | MCHR1KCNH2 | |
| SCHEMBL4732287 | 0.78 | MCHR1 (0.51) | MCHR1DPP4KCNH2DPP8DPP9 | |
| SCHEMBL4887821 | 0.78 | MCHR1 (0.45) | MCHR1SCDDPP4KCNH2DPP8 | |
| SCHEMBL1750254 | 0.77 | ALDH1A1 (0.41) | MCHR1ALDH1A1KDM4EMAPTMCL1 | |
| SCHEMBL1749645 | 0.77 | ALDH1A1 (0.41) | MCHR1ALDH1A1KDM4EMAPTMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041090-A1 | MALANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONIST PYRIDINONES | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |