Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 10/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 5/20 | 0.38 |
| ▸ | THRB | P10828 | 5/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18606621 | 0.80 | GPR17 (0.59) | GPR17NPSR1THRATHRBKEAP1 | |
| SCHEMBL18982683 | 0.79 | NPSR1 (0.44) | GPR17NPSR1THRATHRBKEAP1 | |
| SCHEMBL9637092 | 0.79 | GPR17 (0.57) | GPR17NPSR1THRATHRBKEAP1 | |
| SCHEMBL4299650 | 0.77 | POLB (0.50) | GPR17NPSR1THRATHRBFFAR1 | |
| SCHEMBL15692965 | 0.76 | NPSR1 (0.44) | GPR17NPSR1THRATHRBKEAP1 | |
| SCHEMBL4035681 | 0.75 | GPR17 (0.57) | GPR17THRATHRBKEAP1FFAR1 | |
| SCHEMBL10495792 | 0.73 | GPR17 (0.41) | GPR17NPSR1THRATHRBKEAP1 | |
| SCHEMBL10495701 | 0.71 | GPR17 (0.39) | GPR17NPSR1THRATHRBKEAP1 | |
| SCHEMBL10495683 | 0.69 | GPR17 (0.38) | GPR17NPSR1THRATHRBFFAR1 | |
| SCHEMBL11406069 | 0.69 | KEAP1 (0.41) | GPR17NPSR1KEAP1FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |