Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4798176 | 0.89 | GRM1 (0.55) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4780726 | 0.88 | MAPT (0.53) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3341845 | 0.85 | MAPT (0.60) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4799462 | 0.84 | RAB9A (0.56) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4800674 | 0.84 | GRM1 (0.57) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4797120 | 0.81 | GRM1 (0.59) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3341175 | 0.81 | GRM1 (0.59) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4799172 | 0.81 | MAPT (0.49) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4797546 | 0.81 | RAB9A (0.55) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4795303 | 0.79 | MAPT (0.47) | MAPTRAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | claimed |
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |