Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202534 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2PIM1CA1CA2POLB | |
| SCHEMBL8213736 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2 | |
| SCHEMBL8203895 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2 | |
| SCHEMBL4729890 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2 | |
| SCHEMBL5909919 | 0.75 | SIRT2 (0.40) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8210999 | 0.75 | SSTR2 (0.40) | PIM1CA2NSD2 | |
| SCHEMBL22617257 | 0.71 | MAOB (0.60) | SMN1; SMN2MAPTKDM4EADORA3AR | |
| SCHEMBL22617253 | 0.71 | MAOB (0.60) | SMN1; SMN2MAPTKDM4EADORA3AR | |
| SCHEMBL22617487 | 0.71 | MAOB (0.60) | SMN1; SMN2MAPTKDM4EADORA3AR | |
| SCHEMBL4931666 | 0.71 | MAOB (0.60) | SMN1; SMN2MAPTKDM4EADORA3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052088-A1 | CHROMANE DERIVATIVES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | WYETH (US) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008052088-A1 | CHROMANE DERIVATIVES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | WYETH (US) | 2008-05-02 | — | — | WO | disclosed |