Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 15/20 | 0.54 |
| ▸ | MC5R | P33032 | 2/20 | 0.54 |
| ▸ | MC3R | P41968 | 2/20 | 0.54 |
| ▸ | TACR1 | P25103 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519231 | 1.00 | MC4R (0.54) | MC4RMC5RMC3RTACR1LMNA | |
| SCHEMBL4532240 | 0.90 | TACR1 (0.54) | MC4RTACR1LMNAGLATSHR | |
| SCHEMBL4525985 | 0.89 | MC4R (0.60) | MC4RTACR1LMNAGLATSHR | |
| SCHEMBL4520314 | 0.89 | MC4R (0.53) | MC4RMC5RMC3RTACR1LMNA | |
| SCHEMBL4519175 | 0.89 | MC4R (0.59) | MC4RMC5RMC3RTACR1LMNA | |
| SCHEMBL4514865 | 0.88 | TACR1 (0.52) | MC4RMC5RMC3RTACR1LMNA | |
| SCHEMBL4513687 | 0.88 | TACR1 (0.53) | MC4RTACR1LMNAGLATSHR | |
| SCHEMBL4505547 | 0.87 | LMNA (0.56) | MC4RTACR1LMNAGLATSHR | |
| SCHEMBL4521308 | 0.87 | TACR1 (0.51) | MC4RMC5RMC3RTACR1LMNA | |
| SCHEMBL4509742 | 0.87 | TACR1 (0.51) | MC4RMC5RMC3RTACR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | disclosed |