Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.37 |
| ▸ | KDR | P35968 | 7/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MST1R | Q04912 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732266 | 0.90 | MET (0.37) | METKDRGPR119MST1RIDO1 | |
| SCHEMBL2287272 | 0.81 | MET (0.48) | METKDR | |
| SCHEMBL2280815 | 0.75 | MET (0.48) | METKDR | |
| SCHEMBL2282791 | 0.71 | MET (0.48) | METKDR | |
| SCHEMBL2280904 | 0.71 | MET (0.42) | METKDRGPR119IDO1 | |
| SCHEMBL26015597 | 0.70 | MET (0.51) | METGPR119SCN9A | |
| SCHEMBL2285176 | 0.69 | MET (0.41) | METKDR | |
| SCHEMBL13166940 | 0.69 | CHEK2 (0.46) | METKDRGPR119MST1R | |
| SCHEMBL12376903 | 0.68 | MET (0.52) | METKDRMST1R | |
| SCHEMBL12411907 | 0.67 | MET (0.51) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989211-A2 | HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | Array Biopharma, Inc. (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2008063202-A2 | HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | ARRAY BIOPHARMA INC. (US) | 2008-05-29 | — | — | WO | disclosed |