SCHEMBL4733786

SCHEMBL4733786

N#Cc1ccc(C2CCN(C(=O)c3cccc(NC(=O)OCc4ccccc4)c3)CC2)cc1

nearest known ligand 0.51

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FASN P49327 12/20 0.51
KDM1A O60341 1/20 0.49
MAOA P21397 1/20 0.49
KDM1B Q8NB78 1/20 0.49
RCOR1 Q9UKL0 1/20 0.49
TGM2 P21980 1/20 0.49
MGLL Q99685 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4734336 0.86 FASN (0.56) FASN
SCHEMBL4736514 0.85 FASN (0.58) FASN
SCHEMBL4738019 0.85 FASN (0.53) FASN
SCHEMBL4735885 0.85 FASN (0.52) FASN
SCHEMBL4735570 0.85 FASN (0.53) FASN
SCHEMBL4202987 0.85 FASN (0.54) FASN
SCHEMBL4734941 0.84 FASN (0.53) FASN
SCHEMBL4733791 0.82 FASN (0.49) FASN
SCHEMBL4170891 0.82 FASN (0.55) FASN
SCHEMBL4738101 0.81 FASN (0.54) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008075077-A1 PIPERIDINE DERIVATIVES FOR THE TREATMENT OF OBESITY ASTRAZENECA AB (SE) 2008-06-26 WO claimed
WO-2008075077-A1 PIPERIDINE DERIVATIVES FOR THE TREATMENT OF OBESITY ASTRAZENECA AB (SE) 2008-06-26 WO disclosed