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SCHEMBL4733845

SCHEMBL4733845

O=C(c1ccc(F)cc1)N1CCC(NS(=O)(=O)c2ccc(Br)cc2C(F)(F)F)CC1

nearest known ligand 0.55

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 14/20 0.55
▸ HSD11B1 P28845 4/20 0.49
▸ LMNA P02545 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ WNT3 P56703 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4786462 0.92 SFRP1 (0.64) SFRP1HSD11B1WNT3
SCHEMBL4737962 0.92 SFRP1 (0.55) SFRP1WNT3
SCHEMBL4734555 0.91 SFRP1 (0.65) SFRP1WNT3
SCHEMBL4731873 0.90 SFRP1 (0.52) SFRP1HSD11B1LMNAWNT3
SCHEMBL4784461 0.90 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4783487 0.90 SFRP1 (0.64) SFRP1WNT3
SCHEMBL4734400 0.89 SFRP1 (0.53) SFRP1WNT3
SCHEMBL4734495 0.89 SFRP1 (0.54) SFRP1LMNAHTTWNT3
SCHEMBL4786605 0.89 SFRP1 (0.54) SFRP1HSD11B1WNT3
SCHEMBL4731312 0.89 SFRP1 (0.52) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed