SCHEMBL4733858

SCHEMBL4733858

O=C([C@@H]1CCC(=O)N1C(=O)O)N1CCC(NS(=O)(=O)c2ccc(Br)cc2C(F)(F)F)CC1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SFRP1 Q8N474 20/20 0.56
WNT3 P56703 18/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4736828 0.88 SFRP1 (0.59) SFRP1WNT3
SCHEMBL4734111 0.85 SFRP1 (0.51) SFRP1WNT3
SCHEMBL4733972 0.84 SFRP1 (0.59) SFRP1WNT3
SCHEMBL4731423 0.84 SFRP1 (0.59) SFRP1WNT3
SCHEMBL4734235 0.83 SFRP1 (0.54) SFRP1WNT3
SCHEMBL4732393 0.81 SFRP1 (0.54) SFRP1WNT3
SCHEMBL4734367 0.81 SFRP1 (0.54) SFRP1WNT3
SCHEMBL4636587 0.81 SFRP1 (0.83) SFRP1WNT3
SCHEMBL6103803 0.81 SFRP1 (0.83) SFRP1WNT3
SCHEMBL4735095 0.80 SFRP1 (0.66) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 WO disclosed