Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | BRD2 | P25440 | 4/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.41 |
| ▸ | WNT3 | P56703 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732359 | 0.89 | BRD4 (0.36) | BRD4BRD2BRD3HTTTSHR | |
| SCHEMBL4731366 | 0.89 | HTT (0.36) | BRD4BRD2BRD3HTTTSHR | |
| SCHEMBL4731370 | 0.89 | HTT (0.36) | BRD4BRD2BRD3HTTTSHR | |
| SCHEMBL4737035 | 0.87 | BRD4 (0.43) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4735483 | 0.85 | BRD4 (0.41) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4733195 | 0.84 | CCR8 (0.41) | CCR8MEN1KMT2A | |
| SCHEMBL4734862 | 0.84 | MEN1 (0.41) | SFRP1MEN1KMT2A | |
| SCHEMBL4730139 | 0.83 | SFRP1 (0.45) | WNT3SFRP1CCR8MEN1KMT2A | |
| SCHEMBL4730491 | 0.78 | SFRP1 (0.50) | SFRP1MAPTMEN1KMT2A | |
| SCHEMBL4733963 | 0.77 | CNR2 (0.38) | HTTTSHRLMNAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |