SCHEMBL4733949

SCHEMBL4733949

NC(=O)c1ccccc1-c1ccc(S(=O)(=O)NC2CCN(C(=O)O)CC2)c(C(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SFRP1 Q8N474 20/20 0.49
WNT3 P56703 5/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4732156 0.91 SFRP1 (0.49) SFRP1WNT3
SCHEMBL4733043 0.89 SFRP1 (0.55) SFRP1WNT3
SCHEMBL4733138 0.88 SFRP1 (0.50) SFRP1WNT3
SCHEMBL4733959 0.88 SFRP1 (0.50) SFRP1WNT3
SCHEMBL4733131 0.87 SFRP1 (0.49) SFRP1WNT3
SCHEMBL4735298 0.87 SFRP1 (0.54) SFRP1WNT3
SCHEMBL4735911 0.86 SFRP1 (0.54) SFRP1WNT3
SCHEMBL4732357 0.86 SFRP1 (0.51) SFRP1WNT3
SCHEMBL4732557 0.85 SFRP1 (0.48) SFRP1WNT3
SCHEMBL4735311 0.85 SFRP1 (0.51) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 WO disclosed