Sugi Predict

Sugi Predict / Compounds / SCHEMBL4734586

SCHEMBL4734586

SCHEMBL4734586

CC(C)(C)N1CCC(c2cc3nccc(Oc4ccc(NC(=O)c5nccn(-c6ccc(F)cc6)c5=O)cc4F)c3s2)CC1

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ MST1R Q04912 16/20 0.52
▸ MET P08581 4/20 0.52
▸ AXL P30530 2/20 0.52
▸ TYRO3 Q06418 2/20 0.52
▸ MERTK Q12866 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2285562 0.93 MST1R (0.54) MST1RMETAXLTYRO3MERTK
SCHEMBL2280609 0.91 MST1R (0.49) MST1RMETAXLTYRO3MERTK
SCHEMBL2280897 0.89 MET (0.54) MST1RMETAXLTYRO3MERTK
SCHEMBL4730364 0.85 AXL (0.56) METAXLTYRO3MERTK
SCHEMBL2282337 0.80 MET (0.56) MST1RMETAXLTYRO3MERTK
SCHEMBL12376921 0.79 MST1R (0.58) MST1RMETAXLTYRO3MERTK
SCHEMBL14205651 0.79 MET (0.43) MST1RMETAXLTYRO3MERTK
SCHEMBL2282430 0.78 AXL (0.57) MST1RMETAXLTYRO3MERTK
SCHEMBL2281518 0.77 MST1R (0.56) MST1RMET
SCHEMBL2282816 0.77 AXL (0.54) METAXLTYRO3MERTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1989211-A2 HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER Array Biopharma, Inc. (US) 2008-11-12 — — EP disclosed
WO-2008063202-A2 HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER ARRAY BIOPHARMA INC. (US) 2008-05-29 — — WO disclosed