SCHEMBL4734705

SCHEMBL4734705

O=C([C@H]1CCNC1)N1CCC(NS(=O)(=O)c2ccc(-c3ccccc3)cc2C(F)(F)F)CC1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SFRP1 Q8N474 20/20 0.70
WNT3 P56703 10/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4736014 1.00 SFRP1 (0.70) SFRP1WNT3
SCHEMBL4734270 0.86 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4736263 0.86 SFRP1 (0.65) SFRP1WNT3
SCHEMBL4785440 0.86 SFRP1 (0.65) SFRP1WNT3
SCHEMBL4735911 0.85 SFRP1 (0.54) SFRP1WNT3
SCHEMBL4735678 0.85 SFRP1 (0.70) SFRP1WNT3
SCHEMBL4735675 0.85 SFRP1 (0.70) SFRP1WNT3
SCHEMBL4734478 0.84 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4732082 0.84 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4732079 0.84 SFRP1 (0.57) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 WO disclosed