Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112929 | 0.82 | HTT (0.46) | MEN1HTTKMT2APDE10A | |
| SCHEMBL22075845 | 0.75 | ALDH1A1 (0.35) | MEN1HTTKMT2A | |
| SCHEMBL9830230 | 0.75 | KMT2A (0.37) | MEN1HTTKMT2A | |
| SCHEMBL8003108 | 0.75 | HSP90AB1 (0.30) | — | |
| SCHEMBL116212 | 0.75 | HTT (0.37) | MEN1HTTKMT2APDE10A | |
| SCHEMBL10997607 | 0.73 | — | — | |
| SCHEMBL7087209 | 0.71 | PDE10A (0.35) | HTTPDE10A | |
| SCHEMBL1124105 | 0.71 | TDP1 (0.35) | — | |
| SCHEMBL259072 | 0.70 | PDE10A (0.52) | HTTPDE10A | |
| SCHEMBL7298442 | 0.68 | KMT2A (0.34) | MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |