SCHEMBL473478

SCHEMBL473478

COC(=O)C(Br)c1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.49
SLC6A4 P31645 2/20 0.46
SLC6A3 Q01959 2/20 0.46
SLC6A2 P23975 1/20 0.46
BRD4 O60885 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
FFAR2 O15552 2/20 0.43
CNR2 P34972 1/20 0.42
KMT2A Q03164 1/20 0.41
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11562437 0.92 FNTA (0.45) L3MBTL1SLC6A4SLC6A3SLC6A2CNR2
SCHEMBL11565132 0.90 L3MBTL1 (0.43) L3MBTL1SLC6A4SLC6A3SLC6A2BRD4
SCHEMBL11598022 0.87 L3MBTL1 (0.44) L3MBTL1FFAR2CNR2KMT2AALDH1A1
SCHEMBL11596977 0.87 CYP1A2 (0.46) L3MBTL1CNR2KMT2AALDH1A1
SCHEMBL4013605 0.86 L3MBTL1 (0.46) L3MBTL1KMT2AALDH1A1
SCHEMBL11595553 0.86 CYP1A2 (0.45) L3MBTL1CNR2KMT2AALDH1A1
SCHEMBL4776154 0.82 L3MBTL1 (0.45) L3MBTL1KMT2AALDH1A1
SCHEMBL1564938 0.82 CYP1A2 (0.50) KMT2AALDH1A1
SCHEMBL8881032 0.82 ESR1 (0.54) SLC6A3SLC6A2KMT2AALDH1A1
SCHEMBL85762 0.82 BRD4 (0.41) L3MBTL1BRD4HDAC4HDAC7HDAC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 218 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1980563-A1 Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate BATTULA, Srinivasa Reddy (IN) 2008-10-15 EP claimed
EP-4720034-A1 NOVEL COMPOUNDS TO TREAT VIRAL INFECTIONS Zydus Lifesciences Limited (IN) 2026-04-08 EP disclosed
US-20250223307-A1 MDM2/MDMX DOUBLE-TARGET INHIBITOR COMPOUND, PRODRUG, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF GLOBAL HEALTH DRUG DISCOVERY INSTITUTE (CN) 2025-07-10 US disclosed
EP-4582420-A1 MDM2/MDMX DOUBLE-TARGET INHIBITOR COMPOUND, PRODRUG, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF Global Health Drug Discovery Institute (CN) 2025-07-09 EP disclosed
US-20250197379-A1 NOVEL RAS INHIBITORS SJP BIOTEC GMBH (CH) 2025-06-19 US disclosed
WO-2024252254-A1 NOVEL COMPOUNDS TO TREAT VIRAL INFECTIONS ZYDUS LIFESCIENCES LIMITED (IN) 2024-12-12 WO disclosed
EP-4395897-A1 NOVEL RAS INHIBITORS KHR Biotec GmbH (DE) 2024-07-10 EP disclosed
CN-118234715-A Novel RAS inhibitors KHR生物技术有限公司 2024-06-21 CN disclosed
CN-118063438-A MDM2/MDMX double-target inhibitor compound, prodrug, pharmaceutical composition, preparation method and application thereof 北京华益健康药物研究中心 2024-05-24 CN disclosed
WO-2024104304-A1 MDM2/MDMX DOUBLE-TARGET INHIBITOR COMPOUND, PRODRUG, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF 北京华益健康药物研究中心 2024-05-23 WO disclosed
US-5246929-A Prophylaxis or treatment of ischemic encephalopathia TANABE SEIYAKU CO., LTD. (JP) 1993-09-21 US disclosed
US-5240938-A Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring MERCK & CO., INC. (US) 1993-08-31 US disclosed
EP-0517812-A1 ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT MERCK & CO. INC. (US) 1992-12-16 EP disclosed
WO-1991011999-A1 ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT MERCK & CO., INC. (US) 1991-08-22 WO disclosed
EP-0441539-A2 Thiazine (or oxazine) derivatives and preparation thereof TANABE SEIYAKU CO., LTD. (JP) 1991-08-14 EP disclosed
US-4882340-A INHIBITS REFLECTIVE CONTRACTION OF URINARY BLADDER TANABE SEIYAKU CO., LTD. (JP) 1989-11-21 US disclosed
US-4829067-A INHIBITORS OF REFLECTIVE CONTRACTION OF BLADDER TANABE SEIYAKU CO., LTD. (JP) 1989-05-09 US disclosed
EP-0306226-A2 A benzofuran derivative and processes for preparing the same Tanabe Seiyaku Co., Ltd. (JP) 1989-03-08 EP disclosed
EP-0270342-A2 A benzo-furan (or -thiophene) derivative and processes for preparing the same Tanabe Seiyaku Co., Ltd. (JP) 1988-06-08 EP disclosed
US-4067996-A HYPOLIPEMIC, HYPOCHOLESTEROLEMIC SYNTHELABO (FR) 1978-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250197379-A1 NOVEL RAS INHIBITORS KRAS, NRAS, HRAS L3MBTL1 1509/4885SLC6A4 4627/4885SLC6A3 4722/4885
US-20250223307-A1 MDM2/MDMX DOUBLE-TARGET INHIBITOR COMPOUND, PRODRUG, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF MDM2, TP53, TP53BP1 L3MBTL1 2120/4885SLC6A4 4155/4885SLC6A3 4397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.