SCHEMBL4734866

SCHEMBL4734866

C[CH]NC(=O)C1CCCC1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.45
HSD17B10 Q99714 1/20 0.45
EPHX1 P07099 1/20 0.42
LMNA P02545 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
NAAA Q02083 1/20 0.40
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
HSD11B1 P28845 2/20 0.39
TSHR P16473 2/20 0.39
MAPK1 P28482 1/20 0.39
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
PTPN1 P18031 1/20 0.38
HPGD P15428 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4390736 0.98 HDAC8 (0.54) HDAC8HDAC6SMN1; SMN2HSD17B10EPHX1
SCHEMBL8696663 0.98 HDAC8 (0.54) HDAC8HDAC6SMN1; SMN2HSD17B10EPHX1
SCHEMBL8691177 0.95
SCHEMBL8695253 0.90
SCHEMBL4396849 0.82 POLB (0.37) HDAC8HDAC6EPHX1MAPK1HTT
SCHEMBL8691320 0.79 HSD17B10 (0.48) HDAC8HDAC6SMN1; SMN2HSD17B10EPHX1
SCHEMBL5847411 0.78 HDAC8 (0.52) HDAC8HDAC6SMN1; SMN2HSD17B10EPHX1
SCHEMBL8690266 0.77 HDAC8 (0.52) HDAC8HDAC6SMN1; SMN2HSD17B10EPHX1
SCHEMBL8692169 0.77 HDAC8 (0.52) HDAC8HDAC6SMN1; SMN2HSD17B10EPHX1
SCHEMBL29229978 0.76 HDAC8 (0.50) HDAC8HDAC6SMN1; SMN2HSD17B10EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008074078-A1 SELECTIVELY DELIVERABLE ISATIN-BASED CYTOTOXIC AGENTS UNIVERSITY OF WOLLONGONG (AU) 2008-06-26 WO disclosed
US-5827863-A Pyrazole derivatives as angiotensin II antagonists J. URIACH & CIA, S.A. (ES) 1998-10-27 US disclosed
EP-0721454-A1 NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST J. URIACH & CIA. S.A. (ES) 1996-07-17 EP disclosed
WO-1996004273-A1 NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST J. URIACH & CIA, S.A. (ES) 1996-02-15 WO disclosed