Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 9/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737164 | 0.86 | JAK1 (0.59) | JAK1JAK3JAK2 | |
| SCHEMBL4736443 | 0.82 | PIK3CB (0.42) | JAK1JAK3JAK2PIK3CAPIK3R1 | |
| SCHEMBL4735212 | 0.80 | HRH4 (0.48) | HRH4JAK1JAK3JAK2PIK3CA | |
| SCHEMBL4738959 | 0.76 | HRH4 (0.55) | HRH4JAK3PIK3CAPIK3R1 | |
| SCHEMBL14162743 | 0.73 | HRH4 (0.43) | HRH4JAK1JAK3JAK2PIK3CA | |
| SCHEMBL30834201 | 0.71 | HRH4 (0.50) | HRH4JAK1JAK3JAK2PIK3CA | |
| SCHEMBL4736588 | 0.69 | AKT2 (0.39) | JAK1JAK3JAK2 | |
| SCHEMBL14320465 | 0.69 | HRH4 (0.78) | HRH4JAK3PIK3CAPIK3R1 | |
| SCHEMBL14320582 | 0.68 | HRH4 (0.76) | HRH4JAK3JAK2PIK3CAPIK3R1 | |
| SCHEMBL4737158 | 0.65 | JAK3 (0.54) | JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |