Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 10/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736583 | 0.79 | CHEK1 (0.46) | AKT2FFAR2CHEK1CHEK2 | |
| SCHEMBL4737164 | 0.79 | JAK1 (0.59) | JAK1JAK2JAK3 | |
| SCHEMBL4739449 | 0.76 | CHEK1 (0.63) | AKT2FFAR2CHEK1CHEK2 | |
| SCHEMBL14163061 | 0.72 | CHEK1 (0.41) | AKT2FFAR2CHEK1CHEK2 | |
| SCHEMBL14162973 | 0.71 | CHEK1 (0.44) | AKT2FFAR2CHEK1CHEK2 | |
| SCHEMBL4735201 | 0.69 | HRH4 (0.48) | JAK1JAK2JAK3 | |
| SCHEMBL3490701 | 0.67 | AKT2 (0.64) | AKT2 | |
| SCHEMBL1002593 | 0.67 | AKT2 (0.57) | AKT2FFAR2CHEK1CHEK2 | |
| SCHEMBL1003219 | 0.66 | HTR2C (0.50) | AKT2 | |
| SCHEMBL4738636 | 0.66 | AOC3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |