Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 8/20 | 0.54 |
| ▸ | WNT3 | P56703 | 2/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.46 |
| ▸ | FEN1 | P39748 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732029 | 0.88 | SFRP1 (0.48) | SFRP1WNT3ALOX5APFEN1BRD4 | |
| SCHEMBL4735520 | 0.88 | SFRP1 (0.55) | SFRP1WNT3ALOX5APFEN1CYP1A2 | |
| SCHEMBL4735337 | 0.87 | SFRP1 (0.54) | SFRP1WNT3ALOX5APFEN1CYP1A2 | |
| SCHEMBL4732022 | 0.87 | SFRP1 (0.54) | SFRP1WNT3ALOX5APFEN1CYP1A2 | |
| SCHEMBL4732944 | 0.85 | SFRP1 (0.62) | SFRP1WNT3ALOX5APFEN1CCR8 | |
| SCHEMBL4732685 | 0.85 | SFRP1 (0.53) | SFRP1WNT3ALOX5APFEN1CYP1A2 | |
| SCHEMBL4734668 | 0.85 | SFRP1 (0.53) | SFRP1WNT3ALOX5APFEN1CYP1A2 | |
| SCHEMBL4734351 | 0.85 | SFRP1 (0.53) | SFRP1WNT3ALOX5APFEN1CYP1A2 | |
| SCHEMBL4732784 | 0.85 | SFRP1 (0.54) | SFRP1WNT3ALOX5APFEN1MEN1 | |
| SCHEMBL4730932 | 0.85 | SFRP1 (0.52) | SFRP1WNT3ALOX5APFEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |