Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | IKBKB | O14920 | 5/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738322 | 0.91 | BRAF (0.62) | BRAFIKBKBMAP4K1CHUK | |
| SCHEMBL4738027 | 0.82 | IKBKB (0.55) | BRAFCDK2IKBKBSRCCDK1 | |
| SCHEMBL4735381 | 0.79 | BRAF (0.78) | BRAF | |
| SCHEMBL4736963 | 0.79 | BRAF (0.68) | BRAFCDK2 | |
| SCHEMBL4736008 | 0.76 | BRAF (0.62) | BRAFMAP4K1 | |
| SCHEMBL14569081 | 0.74 | ABL1 (0.58) | BRAFMAP4K1 | |
| SCHEMBL3521241 | 0.71 | IKBKB (0.74) | CDK2IKBKBCDK1CDK4CHUK | |
| SCHEMBL3516492 | 0.71 | IKBKB (0.72) | CDK2IKBKBCDK1CDK4CHUK | |
| SCHEMBL3522686 | 0.71 | IKBKB (0.72) | CDK2IKBKBCDK1CDK4CHUK | |
| SCHEMBL3520093 | 0.71 | IKBKB (0.72) | CDK2IKBKBCDK1CDK4CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008068507-A2 | 2 -PHENYLAMINO, 6- (PYRID-3-YL) QUINAZOLINE DERIVATIVES AS RAF-PROTEIN KINASE INHIBITORS IN CANCER TREATMENT | ASTRAZENECA AB (SE) | 2008-06-12 | — | — | WO | claimed |