Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.62 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738322 | 0.79 | BRAF (0.62) | BRAFMAP4K1RAF1 | |
| SCHEMBL4735381 | 0.78 | BRAF (0.78) | BRAFRAF1 | |
| SCHEMBL14569081 | 0.77 | ABL1 (0.58) | BRAFMAP4K1ABL1 | |
| SCHEMBL4735339 | 0.76 | BRAF (0.58) | BRAFMAP4K1 | |
| SCHEMBL4736963 | 0.75 | BRAF (0.68) | BRAFRAF1 | |
| SCHEMBL3034030 | 0.74 | BRAF (0.68) | BRAFRAF1 | |
| SCHEMBL5129995 | 0.72 | BRAF (0.77) | BRAFRAF1 | |
| SCHEMBL5495562 | 0.71 | BRAF (0.48) | BRAFMAP4K1ABL1 | |
| SCHEMBL4885707 | 0.71 | BRAF (0.83) | BRAFRAF1 | |
| SCHEMBL4738974 | 0.70 | BRAF (0.53) | BRAFMAP4K1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008068507-A2 | 2 -PHENYLAMINO, 6- (PYRID-3-YL) QUINAZOLINE DERIVATIVES AS RAF-PROTEIN KINASE INHIBITORS IN CANCER TREATMENT | ASTRAZENECA AB (SE) | 2008-06-12 | — | — | WO | claimed |