Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14207912 | 0.77 | MEN1 (0.37) | MEN1KMT2AHSP90AA1ADORA1 | |
| SCHEMBL4734189 | 0.74 | KMT2A (0.46) | KDRMEN1KMT2APOLBMAPT | |
| SCHEMBL4735176 | 0.73 | ADORA1 (0.43) | KDRMEN1KMT2APOLBMAPT | |
| SCHEMBL14208218 | 0.68 | HSP90AA1 (0.37) | MEN1KMT2APOLBHSP90AA1KDM4E | |
| SCHEMBL4735390 | 0.64 | MEN1 (0.36) | KDRMEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL14254903 | 0.60 | TSHR (0.68) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL30540534 | 0.59 | NQO2 (0.43) | MEN1KMT2APOLBMAPTSMN1; SMN2 | |
| SCHEMBL5226002 | 0.59 | TDP1 (0.54) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL344338 | 0.59 | GRM4 (0.57) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL10769731 | 0.58 | KDM4E (0.48) | MEN1KMT2APOLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059368-A2 | FUSED 2-AMINO PYRIMIDINE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | disclosed |