Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 8/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16296825 | 0.81 | EGFR (0.42) | EGFRCSF1R | |
| SCHEMBL28693060 | 0.80 | EGFR (0.40) | EGFR | |
| SCHEMBL16385172 | 0.79 | EGFR (0.38) | EGFRTSHRTAAR1CSF1RKDM4E | |
| SCHEMBL2563499 | 0.78 | EGFR (0.37) | EGFRSIRT1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28598599 | 0.78 | EGFR (0.44) | EGFRHTR2AHTR2CTAAR1HTR2B | |
| SCHEMBL21823500 | 0.78 | ENPP1 (0.40) | EGFRTSHRKDM4E | |
| SCHEMBL13872636 | 0.77 | EGFR (0.42) | EGFRTSHRCSF1R | |
| SCHEMBL17752331 | 0.77 | EGFR (0.45) | EGFRTSHRHTR2AHTR2CTAAR1 | |
| SCHEMBL27191881 | 0.76 | EGFR (0.38) | EGFRTSHRTAAR1CSF1RLMNA | |
| SCHEMBL31118339 | 0.75 | EGFR (0.44) | EGFRTSHRHTR2AHTR2CTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059368-A2 | FUSED 2-AMINO PYRIMIDINE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | disclosed |