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SCHEMBL4735828

SCHEMBL4735828

CN(C)c1ccc(C(=O)N2CCC(NS(=O)(=O)c3ccc(Br)cc3C(F)(F)F)CC2)cn1

nearest known ligand 0.69

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 18/20 0.69
▸ HPGDS O60760 1/20 0.44
▸ WNT3 P56703 4/20 0.43
▸ KDM4E B2RXH2 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4786060 0.88 SFRP1 (0.69) SFRP1WNT3
SCHEMBL4734490 0.88 SFRP1 (0.73) SFRP1WNT3
SCHEMBL4735165 0.87 SFRP1 (0.67) SFRP1WNT3KDM4EHSD17B10
SCHEMBL4734352 0.87 SFRP1 (0.56) SFRP1WNT3KDM4EHSD17B10
SCHEMBL4733610 0.87 SFRP1 (0.66) SFRP1WNT3
SCHEMBL4734093 0.85 SFRP1 (0.53) SFRP1WNT3KDM4EHSD17B10
SCHEMBL4735715 0.85 SFRP1 (0.69) SFRP1HPGDSWNT3KDM4EHSD17B10
SCHEMBL4736713 0.83 SFRP1 (0.69) SFRP1WNT3
SCHEMBL4784461 0.83 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4783487 0.83 SFRP1 (0.64) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed