Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.82 |
| ▸ | FLT3 | P36888 | 14/20 | 0.82 |
| ▸ | KIT | P10721 | 10/20 | 0.82 |
| ▸ | FLT1 | P17948 | 6/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.57 |
| ▸ | CSF1R | P07333 | 4/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | LTK | P29376 | 2/20 | 0.55 |
| ▸ | CDK8 | P49336 | 2/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739871 | 0.90 | KDR (0.67) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL423549 | 0.90 | KDR (1.00) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL1382868 | 0.88 | KDR (0.74) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL4786398 | 0.86 | KDR (0.81) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL421596 | 0.86 | KDR (0.79) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL3394108 | 0.83 | KDR (0.78) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL421556 | 0.82 | KDR (0.78) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL4740259 | 0.82 | KDR (0.59) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL4740470 | 0.81 | KDR (0.76) | KDRFLT3KITFLT1PDGFRB | |
| SCHEMBL4740129 | 0.81 | KDR (0.75) | KDRFLT3KITFLT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080110-A1 | METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR | ALCON, INC. (CH) | 2008-07-03 | — | — | WO | claimed |
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |