Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.59 |
| ▸ | FLT3 | P36888 | 8/20 | 0.59 |
| ▸ | KIT | P10721 | 6/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.55 |
| ▸ | HTR2C | P28335 | 5/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | BLK | P51451 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421068 | 0.90 | KDR (0.69) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4739871 | 0.89 | KDR (0.67) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL1382868 | 0.89 | KDR (0.74) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4736503 | 0.86 | IKBKE (0.65) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL423540 | 0.85 | KDR (0.80) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL5249636 | 0.82 | KDR (0.67) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4735702 | 0.82 | KDR (0.78) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL422682 | 0.82 | KDR (0.74) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4735874 | 0.82 | KDR (0.82) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL1384424 | 0.82 | KDR (0.73) | KDRFLT3KITPDGFRBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080110-A1 | METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR | ALCON, INC. (CH) | 2008-07-03 | — | — | WO | claimed |
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |