Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.87 |
| ▸ | POLB | P06746 | 1/20 | 0.87 |
| ▸ | IKBKB | O14920 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990063 | 0.93 | KDM4E (1.00) | KDM4EALDH1A1POLBIKBKBHTT | |
| SCHEMBL29929816 | 0.93 | KDM4E (1.00) | KDM4EALDH1A1POLBIKBKBHTT | |
| SCHEMBL1509445 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1POLBIKBKBHTT | |
| SCHEMBL15759146 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1POLBIKBKBHTT | |
| SCHEMBL10202581 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1POLBIKBKBHTT | |
| SCHEMBL13262115 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1POLBIKBKBHTT | |
| SCHEMBL14197519 | 0.75 | HRH4 (0.60) | KDM4EALDH1A1POLBMAPTBCHE | |
| SCHEMBL13591828 | 0.75 | KDM4E (0.51) | KDM4EALDH1A1POLBHTTHSP90AA1 | |
| SCHEMBL10670682 | 0.74 | KDM4E (0.67) | KDM4EALDH1A1POLBHTTHSP90AA1 | |
| SCHEMBL11296744 | 0.74 | IKBKB (0.73) | KDM4EALDH1A1POLBIKBKBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060766-A2 | HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060766-A2 | HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |