Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KPNA2 | P52292 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271456 | 0.94 | KDM4E (0.59) | KDM4EALDH1A1POLBIKBKBDUSP10 | |
| SCHEMBL15759146 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1POLBIKBKBDUSP10 | |
| SCHEMBL13373296 | 0.78 | IKBKB (0.55) | KDM4EALDH1A1POLBIKBKBDUSP10 | |
| SCHEMBL10202581 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1POLBIKBKBDUSP10 | |
| SCHEMBL10271457 | 0.77 | ALDH1A1 (0.50) | KDM4EALDH1A1DRD4GAAMEN1 | |
| SCHEMBL4736088 | 0.76 | KDM4E (0.87) | KDM4EALDH1A1POLBIKBKBDRD4 | |
| SCHEMBL1509445 | 0.76 | KDM4E (0.57) | KDM4EALDH1A1POLBIKBKBDUSP10 | |
| SCHEMBL12256547 | 0.72 | KDM4E (0.65) | KDM4EALDH1A1POLBIKBKBDUSP10 | |
| SCHEMBL10272451 | 0.72 | CDK5 (0.43) | MAOB | |
| SCHEMBL13373267 | 0.72 | CYP1A2 (0.58) | KDM4EALDH1A1POLBIKBKBDUSP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264740-A1 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20100168416-A1 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168416-A1 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, ERBB3 | KDM4E 4036/4885ALDH1A1 4540/4885POLB 3711/4885 |
| US-20120264740-A1 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, ERBB3 | KDM4E 4036/4885ALDH1A1 4540/4885POLB 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.