Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | TTK | P33981 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | ITK | Q08881 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377153 | 0.84 | MAPK14 (0.52) | NTRK1TTKHTR2AHTR2CHTR2B | |
| SCHEMBL8253009 | 0.82 | CSNK1D (0.49) | NTRK1TTKGSK3AGSK3BDYRK1A | |
| SCHEMBL27542244 | 0.81 | TTK (0.46) | NTRK1TTKLRRK2MAPK1MAP2K4 | |
| SCHEMBL4840184 | 0.81 | ENPP1 (0.61) | GSK3AGSK3BDYRK1AMAPK14ITK | |
| SCHEMBL8251865 | 0.80 | MAP2K4 (0.68) | TTKHTR2AHTR2CHTR2BGSK3A | |
| SCHEMBL5374591 | 0.80 | MAP2K4 (0.71) | NTRK1ITKMAPK1MAP2K4 | |
| SCHEMBL4009086 | 0.79 | AXL (0.55) | TTKHTR2AHTR2CHTR2BGSK3A | |
| SCHEMBL5453654 | 0.78 | NTRK1 (0.43) | NTRK1TTKHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL5390659 | 0.78 | AXL (0.53) | TTKHTR2AHTR2CHTR2BGSK3A | |
| SCHEMBL5516414 | 0.77 | MKNK1 (0.62) | TTKGSK3AGSK3BDYRK1AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |