Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736181 | 0.78 | NTRK1 (0.56) | NTRK1MAPK1LRRK2MAPK13ALOX5 | |
| SCHEMBL5377153 | 0.72 | MAPK14 (0.52) | NTRK1MAPK1CSNK1DMAPK13ALOX5 | |
| SCHEMBL8253009 | 0.70 | CSNK1D (0.49) | NTRK1MAPK1CSNK1DMAPK13ALOX5 | |
| SCHEMBL8251865 | 0.69 | MAP2K4 (0.68) | MAPK1HTR2AHTR2CHTR2BPRKAG1 | |
| SCHEMBL4009086 | 0.68 | AXL (0.55) | MAPK1LRRK2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL5390659 | 0.67 | AXL (0.53) | MAPK1LRRK2HTR2AHTR2CHTR2B | |
| SCHEMBL5377845 | 0.66 | AR (0.46) | NTRK1MAPK1CSNK1DHTR2AMAP2K4 | |
| SCHEMBL5374591 | 0.66 | MAP2K4 (0.71) | NTRK1MAPK1CSNK1DITKMAP2K4 | |
| SCHEMBL27542244 | 0.65 | TTK (0.46) | NTRK1MAPK1LRRK2CSNK1DTTK | |
| SCHEMBL5385898 | 0.65 | LRRK2 (0.59) | LRRK2HTR2AHTR2CHTR2BPRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060616-A1 | Methods for treating, preventing and managing chronic lymphocytic leukemia with indazole compounds | SIGNAL PHARMACEUTICALS, LLC | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060616-A1 | Methods for treating, preventing and managing chronic lymphocytic leukemia with indazole compounds | BCL9, MCL1, INMT | NTRK1 4786/4885MAPK1 2816/4885SRC 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.