Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737061 | 0.90 | CHEK1 (0.65) | CHEK1CHEK2PDE10APDE4BALDH1A1 | |
| SCHEMBL4737214 | 0.89 | CHEK1 (0.59) | CHEK1CHEK2PDE10APDE4BALDH1A1 | |
| SCHEMBL4738311 | 0.89 | CHEK1 (0.64) | CHEK1CHEK2PDE10APDE4BALDH1A1 | |
| SCHEMBL14163041 | 0.86 | CHEK1 (0.86) | CHEK1CHEK2PDE10APDE4BADORA1 | |
| SCHEMBL14162805 | 0.86 | CHEK1 (0.86) | CHEK1CHEK2PDE10APDE4BADORA1 | |
| SCHEMBL4735382 | 0.83 | CHEK1 (0.58) | CHEK1CHEK2PDE10APDE4BALDH1A1 | |
| SCHEMBL4738914 | 0.80 | CHEK1 (0.63) | CHEK1CHEK2PDE10AHDAC6PDE4B | |
| SCHEMBL4738683 | 0.79 | CHEK1 (0.75) | CHEK1CHEK2HDAC6PDE4BALDH1A1 | |
| SCHEMBL14162782 | 0.79 | CHEK1 (0.70) | CHEK1CHEK2PDE4BALDH1A1JAK3 | |
| SCHEMBL14162773 | 0.79 | CHEK1 (0.67) | CHEK1CHEK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |