Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.75 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738914 | 0.89 | CHEK1 (0.63) | CHEK1CHEK2PDE4BJAK3JAK2 | |
| SCHEMBL14162764 | 0.86 | CHEK1 (0.74) | CHEK1CHEK2PDE4BJAK3PAK1 | |
| SCHEMBL4803059 | 0.86 | CHEK1 (1.00) | CHEK1CHEK2PDE4B | |
| SCHEMBL14162773 | 0.84 | CHEK1 (0.67) | CHEK1CHEK2JAK3JAK2JAK1 | |
| SCHEMBL14162782 | 0.83 | CHEK1 (0.70) | CHEK1CHEK2PDE4BJAK3PAK1 | |
| SCHEMBL4737061 | 0.80 | CHEK1 (0.65) | CHEK1CHEK2PDE4BJAK3PAK1 | |
| SCHEMBL4737083 | 0.79 | CHEK1 (0.64) | CHEK1CHEK2PDE4BJAK3ALDH1A1 | |
| SCHEMBL14162801 | 0.79 | CHEK1 (0.86) | CHEK1CHEK2PDE4B | |
| SCHEMBL4738639 | 0.79 | CHEK1 (1.00) | CHEK1CHEK2AKT2 | |
| SCHEMBL21067384 | 0.79 | CHEK1 (1.00) | CHEK1CHEK2AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |