Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278384 | 0.88 | CES2 (0.56) | CES2CES1MEN1KMT2APTPN1 | |
| SCHEMBL31298356 | 0.81 | CES2 (0.48) | CES2CES1MEN1KMT2APTPN1 | |
| SCHEMBL12780415 | 0.81 | CA9 (0.48) | CES2CES1MEN1KMT2ACA12 | |
| SCHEMBL30016040 | 0.79 | KMT2A (0.56) | CES2CES1MEN1KMT2AMAPT | |
| SCHEMBL3467976 | 0.79 | KMT2A (0.56) | CES2CES1MEN1KMT2AMAPT | |
| SCHEMBL27203878 | 0.78 | KMT2A (0.51) | CES2CES1MEN1KMT2ACA12 | |
| SCHEMBL11581348 | 0.78 | NR4A2 (0.46) | CES2CES1MEN1KMT2ACA12 | |
| SCHEMBL12533486 | 0.77 | CA12 (0.48) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL2096065 | 0.77 | CES2 (0.44) | CES2CES1MEN1KMT2APTPN1 | |
| SCHEMBL617480 | 0.75 | CA12 (0.70) | CES2CES1MEN1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2008084067-A2 | PHARMACEUTICALLY ACTIVE DIHYDROBENZOFURANE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-07-17 | — | — | WO | disclosed |