Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.38 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740750 | 0.82 | TYMS (0.46) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL14148129 | 0.82 | TYMS (0.35) | TYMS | |
| SCHEMBL4739932 | 0.73 | EGFR (0.40) | TYMSLMNAMAPT | |
| SCHEMBL204100 | 0.70 | SRD5A1 (0.64) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL31268305 | 0.70 | SRD5A1 (0.64) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL1869749 | 0.67 | CYP19A1 (0.47) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL6651001 | 0.67 | TYMS (0.59) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL4817935 | 0.66 | SRD5A1 (0.60) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL20229560 | 0.65 | TYMS (0.47) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL20797143 | 0.65 | SRD5A1 (0.57) | TYMSSRD5A1SRD5A2CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |