Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.76 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457625 | 0.88 | SMN1; SMN2 (1.00) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL30361161 | 0.86 | SMN1; SMN2 (0.77) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4731357 | 0.83 | CA12 (0.61) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL30361143 | 0.81 | HTT (0.68) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL27182285 | 0.80 | HTT (0.80) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL15292803 | 0.79 | SMN1; SMN2 (0.69) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10719972 | 0.79 | HTT (0.78) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10723602 | 0.78 | MGLL (0.67) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3455702 | 0.76 | HTT (0.91) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3459407 | 0.76 | HTT (0.63) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |