Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DNM1L | O00429 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738932 | 0.91 | GAA (0.41) | GAATSHRHTTSMN1; SMN2RAB9A | |
| SCHEMBL4739012 | 0.90 | GAA (0.40) | GAATSHRPDK1HTTSMN1; SMN2 | |
| SCHEMBL4738302 | 0.90 | GAA (0.40) | GAATSHRHTTSMN1; SMN2RAB9A | |
| SCHEMBL4735442 | 0.89 | AR (0.43) | GAATSHRPDK1HTTSMN1; SMN2 | |
| SCHEMBL4737103 | 0.89 | GAA (0.43) | GAATSHRHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL4738953 | 0.85 | GAA (0.40) | GAATSHRHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL4737961 | 0.85 | GAA (0.39) | GAATSHRHTTSMN1; SMN2MAPK1 | |
| SCHEMBL3066965 | 0.82 | SMN1; SMN2 (0.43) | GAATSHRHTTSMN1; SMN2RAB9A | |
| SCHEMBL4736625 | 0.80 | SMN1; SMN2 (0.39) | GAATSHRHTTSMN1; SMN2RAB9A | |
| SCHEMBL4786765 | 0.80 | GAA (0.51) | GAATSHRHTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |