Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.56 |
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2822394 | 1.00 | MTNR1A (0.56) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL2980372 | 1.00 | MTNR1A (0.56) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL4739536 | 0.92 | ACE (0.49) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL5127845 | 0.92 | ACE (0.49) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL4739541 | 0.92 | ACE (0.49) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL5125134 | 0.90 | MME (0.51) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL2822813 | 0.90 | MME (0.51) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL4738105 | 0.88 | ADRB3 (0.50) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL4738108 | 0.88 | ADRB3 (0.50) | MTNR1AMTNR1BACEPSEN1PSEN2 | |
| SCHEMBL5119350 | 0.85 | PSEN1 (0.43) | MTNR1AMTNR1BACEPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1958939-A2 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | Pfizer Products Inc. (US) | 2008-08-20 | — | — | EP | claimed |
| EP-1735285-B1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-07-23 | — | — | EP | claimed |
| US-7384968-B2 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2008-06-10 | — | — | US | claimed |
| US-20070265327-A1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. | 2007-11-15 | — | — | US | claimed |
| US-7244757-B2 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC (US) | 2007-07-17 | — | — | US | claimed |
| US-7232820-B2 | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC (US) | 2007-06-19 | — | — | US | claimed |
| EP-1735294-A1 | THIADIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Incorporated (US) | 2006-12-27 | — | — | EP | claimed |
| EP-1735285-A2 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Incorporated (US) | 2006-12-27 | — | — | EP | claimed |
| EP-1735292-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-12-27 | — | — | EP | claimed |
| US-20060084689-A1 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC. | 2006-04-20 | — | — | US | claimed |
| WO-2005095368-A1 | THIADIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | claimed |
| WO-2005095367-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | claimed |
| WO-2005095348-A2 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | claimed |
| US-20050222219-A1 | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC | 2005-10-06 | — | — | US | claimed |
| US-20050222239-A1 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC | 2005-10-06 | — | — | US | claimed |
| US-7468386-B2 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20080207712-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. | 2008-08-28 | — | — | US | disclosed |
| WO-2005095368-A1 | THIADIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |
| US-20050222239-A1 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC | 2005-10-06 | — | — | US | disclosed |
| US-20050222219-A1 | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222239-A1 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | APP, PRNP, BACE1 | MTNR1A 142/4885MTNR1B 110/4885ACE 1207/4885 |
| US-20080207712-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | APP, PSEN1, BACE1 | MTNR1A 28/4885MTNR1B 23/4885ACE 927/4885 |
| US-20070265327-A1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | APP, PRNP, BACE1 | MTNR1A 142/4885MTNR1B 110/4885ACE 1207/4885 |
| US-20050222219-A1 | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders | APP, BACE1, PSEN1 | MTNR1A 55/4885MTNR1B 64/4885ACE 1906/4885 |
| US-20060084689-A1 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | APP, PSEN1, BACE1 | MTNR1A 28/4885MTNR1B 23/4885ACE 927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.