Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653339 | 0.85 | SRD5A1 (0.44) | SRD5A1SRD5A2KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL10429668 | 0.80 | SRD5A1 (0.61) | SRD5A1SRD5A2KDM4ECYP1A2MEN1 | |
| SCHEMBL6648388 | 0.75 | ALDH1A1 (0.42) | KDM4ESMN1; SMN2L3MBTL1APAF1SMAD3 | |
| SCHEMBL14710227 | 0.75 | SRD5A1 (0.48) | SRD5A1SRD5A2SMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL23649905 | 0.72 | CYP1A2 (0.40) | SRD5A1SRD5A2KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL30121173 | 0.72 | CYP1A2 (0.40) | SRD5A1SRD5A2KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL6536547 | 0.71 | SRD5A1 (0.50) | SRD5A1SRD5A2CYP1A2MAPTNPC1 | |
| SCHEMBL9134338 | 0.71 | SMAD3 (0.42) | SRD5A1SRD5A2KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL15529034 | 0.71 | MAPT (0.41) | KDM4ESMN1; SMN2L3MBTL1CYP1A2MEN1 | |
| SCHEMBL13790503 | 0.71 | ALDH1A1 (0.51) | KDM4ESMN1; SMN2L3MBTL1CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |