Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 15/20 | 0.55 |
| ▸ | PPARD | Q03181 | 7/20 | 0.51 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740499 | 0.93 | PPARA (0.55) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL14146355 | 0.90 | PPARA (0.45) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL4741580 | 0.89 | PPARA (0.56) | PPARAPPARDPPARGALDH1A1NPC1 | |
| SCHEMBL4737357 | 0.84 | MAPT (0.43) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL14146453 | 0.83 | MAPT (0.49) | PPARAPPARDMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4739679 | 0.83 | PPARA (0.57) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL4738885 | 0.83 | MAPT (0.49) | PPARAMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14146844 | 0.81 | PPARA (0.51) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL14146852 | 0.81 | PPARA (0.52) | PPARAPPARDPPARGALDH1A1NPC1 | |
| SCHEMBL4739678 | 0.79 | PPARA (0.62) | PPARAPPARDPPARGALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |