Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.47 |
| ▸ | AR | P10275 | 3/20 | 0.44 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474038 | 0.90 | HSD11B1 (0.43) | HSD11B1ARKIF11PTPN5PDE2A | |
| SCHEMBL473960 | 0.88 | AR (0.41) | HSD11B1ARPTPN5 | |
| SCHEMBL473964 | 0.85 | HSD11B1 (0.43) | HSD11B1ARKIF11TNF | |
| SCHEMBL473894 | 0.85 | HSD11B1 (0.43) | HSD11B1ARTNF | |
| SCHEMBL12164142 | 0.85 | HSD11B1 (0.43) | HSD11B1ARKIF11TNF | |
| SCHEMBL12164141 | 0.85 | HSD11B1 (0.43) | HSD11B1ARTNF | |
| SCHEMBL473998 | 0.84 | AR (0.47) | HSD11B1ARKIF11PDE2A | |
| SCHEMBL15520327 | 0.83 | HSD11B1 (0.41) | HSD11B1ARKIF11TNFCYP11B1 | |
| SCHEMBL15520147 | 0.82 | HSD11B1 (0.41) | HSD11B1ARKIF11TNFCYP11B1 | |
| SCHEMBL473957 | 0.81 | AR (0.41) | HSD11B1ARPTPN5TNFCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-A1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | claimed |
| EP-2411365-A1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | disclosed |