Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | MAOA | P21397 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10782592 | 0.80 | TSHR (0.44) | MAOACYP1A2TSHRCYP2D6ADRA2B | |
| SCHEMBL20028832 | 0.77 | SLC1A3 (0.46) | MAOBCYP1A2TSHRCYP2D6MAPK1 | |
| SCHEMBL27705296 | 0.75 | ADRA2B (0.42) | MAOBMAOACYP1A2TSHRCYP2D6 | |
| SCHEMBL11675406 | 0.75 | TSHR (0.40) | CYP1A2TSHRCYP2D6ADRA2BADRA2C | |
| SCHEMBL28499565 | 0.74 | MAOB (0.43) | MAOBMAOACYP1A2TSHRCYP2D6 | |
| SCHEMBL28499564 | 0.74 | MAOB (0.43) | MAOBMAOACYP1A2TSHRCYP2D6 | |
| SCHEMBL31059752 | 0.74 | MAOB (0.43) | MAOBMAOACYP1A2TSHRCYP2D6 | |
| SCHEMBL4505788 | 0.74 | RCE1 (0.39) | CYP1A2TSHRCYP2D6ADRA2BADRA2C | |
| SCHEMBL8614055 | 0.73 | BCHE (0.46) | CYP1A2TSHRCYP2D6ADRA2BADRA2A | |
| SCHEMBL11465303 | 0.73 | TSHR (0.43) | CYP1A2TSHRCYP2D6ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | claimed |